Therapeutic Applications of Oligonucleotides describes antisense RNA technology and how it can be used to treat disease. The book covers the mechanisms of antisense action and the preparation and delivery of antisense oligonucleotides. This innovative therapy for diseases as diverse as cancer, viral infection and atherosclerosis acts to interrupt protein production by very specifically preventing translation from targeted RNA. In an animal model antisense RNA has been effective in reducing restenosis after angioplasty. The audience for this book includes physicians who will be using this new treatment as well as researchers who want to learn how to enhance their work by applying the techniques of this exciting field.